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Independent News Express > Blog > Health > First WHO’s Guidance On Snakebite Treatments Published
Health

First WHO’s Guidance On Snakebite Treatments Published

Last updated: 2023/06/23 at 5:29 PM
2 years ago
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The World Health Organization (WHO) has published the first in a series of WHO public-benefit target product profiles (TPPs) for snakebite treatments, in order to improve the quality of antivenoms available in the market.

This is the first-ever guidance to improve the quality of such products.

The TPP is a document that provides regulators, manufacturers, researchers and procurement agencies with essential information about the minimum and optimum characteristics of specific products for specific use cases, in this case, antivenoms used for the treatment of snakebites caused by various types of sub-Saharan African snakes.

TPPs help to ensure that products are designed and manufactured to meet the match the clinical needs of populations at risk, and are “fit-for-use” – e.g., are safe, effective and adapted to the use environment,

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A high-quality antivenom provides the best available treatment for approximately 5.4 million people who are bitten by snakes each year. Safe, effective antivenoms could prevent many of the 83 000-138 000 deaths caused by snakebites and reduce the severity of serious disabilities that impact many thousands more victims.

“Access to high quality, safe and effective antivenom is an issue of equity and this critical work brings us one step forward in being able to make this a reality” Dr Socé Fall, Director of the WHO Global NTD Programme.

Antivenoms have been made for some 130 years and yet, remarkably, there has been until now, no guidance on how to design and manufacture a product of high quality that meets the correct requirements for safety, effectiveness, and functional use.

The first of these is for products that are intended for widespread use throughout sub-Saharan Africa, for treatment of snakebites irrespective of the species of snake causing the bite. The second is for treatment of bites from a single species (or group) of snake(s). Products in both these categories are currently on the market.

The other two categories are for products that do not yet exist in sub-Saharan Africa, but evidence from other parts of the world suggests that if developed they may have a useful role to play. One of these new product types is for antivenoms where the snakebite mainly causes a syndrome dominated by neurotoxic effects, while the other is intended for non-neurotoxic snakebite syndromes that involve effects on blood clotting or tissue necrosis without paralytic effects.

These TPPs, are intended to provide guidance to manufacturers, regulators, procurement agencies, clinicians and researchers and will contribute to improvements in the quality, safety and effectiveness of antivenoms and thus better treatment of snakebites.

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TAGGED: Snakebite Treatments, WHO
INadminNG June 23, 2023 June 23, 2023
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